Dr Naides is employed by Quest Diagnostics. If the technology is commercially successful in the future, Dr Markert and Duke University may benefit financially. Portions of Dr Markert and her research team’s salaries are being paid by the funding from Enzyvant. Dr Markert has received royalties from Enzyvant. Schuler W, Weiler IJ, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ (1986) Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.POTENTIAL CONFLICT OF INTEREST: Dr Markert developed technology for RVT-802, which has been licensed to Enzyvant Therapeutics GmbH. Malissen M, Minard K, Mjolsness S, Kronenberg M, Goverman J, Hunkapillar T, Prystowsky MB, Yoshikai Y, Fitch F, Mak TW, Hood L (1984) Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the ß polypeptide. Leo OM, Too DH, Sachs D, Samelson L, Bluestone JA (1987) Identification of a monoclonal antibody specific for a murine T3 polypeptide. ![]() Ledbetter JA, Herzenberg LA (1979) Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Iwamoto A, Rupp F, Ohashi PS, Walker CL, Pircher H, Joho R, Hengartner H, Mak TW (1986) T cell specific y genes in C57BL/10 mice. Gibson D, Bosma GC, Bosma MJ (1989) Limited clonal diversity of serum immunoglobulin in leaky scid mice, this volume Nature 330: 722–727ĭialynas DB, Wilde P, Marrack A, Pierres KA, Wall W, Hairan G, Otten MR, Loken M, Pierres J, Kappler J, Fitch FW (1983) Characterization of the murine antigenic determinant, designated 元T4a, recognized by monoclonal antibody GK1.5: Expression of 元T4a by functional T cell clones appears to correlate primarily with class II MHC antigen reactivity. Nature 327: 677–682Ĭhien, Y, Iwashima M, Wettstein DA, Kaplan KB, Elliott JF, Born W, Davis MM (1987b) T-cell receptor S gene rearrangements in early thymocytes. J Immunol (in press).Ĭhien Y, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987a) A new T-cell receptor gene located within the alpha locus and expressed early in T cell differentiation. Eur J Immunol 18: 1965–1971Ĭarroll AM, Hardy RR, Bosma MJ (1989) Occurrence of mature B (IgM +, B220 +) and T (CD3 +) lymphocytes in scid mice. J Exp Med 167: 1016–1033Ĭarroll AM, Bosma MJ (1988) Detection and characterization of functional T cells in mice with severe combined immune deficiency. This process is experimental and the keywords may be updated as the learning algorithm improves.īosma GC, Fried M, Custer RP, Carroll AM, Gibson DM, Bosma MJ (1988) Evidence of functional lymphocytes in some (leaky) scid mice. These keywords were added by machine and not by the authors. ![]() ![]() ![]() Scid Ig + mice generally fail to express all of the major serum Ig classes ( i.e., IgM, IgG3, IgG1, IgG2a, IgG2b and IgA), and isoelectric focusing of serum Ig light chains indicates only one to seven Ig-producing clones in most mice (Bosma et al. The frequency of scid Ig + mice increases with age, and mice housed under non-specific-pathogen free (SPF) conditions show a higher incidence of leakiness than SPF mice, suggesting that naturally-occurring antigens play an important role in the expansion of leaky B cell clones. Leakiness appears to be due to a somatic event as scid mice cannot be selectively bred for this phenotype (G. A variable percentage (~10–20%) of young adult scid mice produce detectable serum Ig, and have been designated “leaky”, or scid Ig + mice (Bosma et al.
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